The Role of Cannabinoid Signaling in Acute and Chronic Kidney Diseases

Chronic Kidney Diseases and the role of the cannabinoids

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The Kidney is one of the most important organs of the human body – with its main job being to filter the blood of the human body. When this organ fails, the human body runs the risk of developing many life-threatening complications and even ultimately, death itself. When a kidney runs into a condition which would affect the condition of it, it encounters what is known as Kidney disease, or otherwise known as renal failure. Kidney disease is a prevalent condition world-wide that often decreases the quality of the sufferers life to an almost unbearable point. It is otherwise known as a more medically classified term, renal fibrosis. It is separated into two different distinct forms, acute and chronic.

Acute kidney disease happens after a severe physical trauma to the body while chronic is caused by more serious medical conditions such as hepatitis C or HIV. It’s also much slower to develop. With each condition, painful symptoms occur often only nominally managed by regulating opiates. Appetite can be lost, sleep can be disturbed, and an overall loss of energy will be felt – making weight gain a significant possibility. Swelling or inflammation of the kidneys could become so painful that ultimately a variety of treatments must be considered. Since sudden weight gain could lead to a host of different things, one such as diabetes, this is of pivotal concern to your health.

Cannabis and Kidney Disease

The cannabinoid receptors found in the human brain and throughout the human body have been found to interact in a therapeutic sense in terms of preventing future renal fibrosis, and other existing kidney problems. As well, it helps regulate unnecessary proteins that can often stockpile in the blood with the appearance of these problems. Typical ways to treat kidney failure include dialysis and a variety of different drugs that manage the many symptoms and complications that come with kidney disease. These treatments and drugs in of themselves can give off uncomfortable side effects that lower the quality of life significantly, forcing patients to take ACE-inhibitor drugs or other opiates. Endo-cannabinoids, which are the receptors found in cannabis itself, has been found to bind with proteins located in the periphery of the body, or otherwise known as the kidney.

The CB receptors in the kidney become drained when there are signs of stress or injury, and link together with the endocannabinoids to provide the relief that cannabis offers. As these receptors are flushed, they filter the endocannabinoids through the blood-stream, decreasing blood pressure and filtering the blood further. This decreases pain, mimicking the effects of many of the pain-relieving drugs prescribed to treat kidney disease. For this reason, a full CB receptor, while unable to prevent or fully treat the condition, can significantly help treat the symptoms and complications that stem from kidney disease or renal failure.

Click here to read the research paper.

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